Research Paper Volume 14, Issue 22 pp 8900—8913

Denervation induces mitochondrial decline and exacerbates lysosome dysfunction in middle-aged mice


Figure 1. Overview of study design and changes in muscle mass with age in the absence and presence of 1, 3 or 7 days of denervation. (A) Schematic representation of the study design. Middle-aged mice (MA, ~15 months old) underwent unilateral sciatic denervation for 1, 3 or 7 days. Young mice (YC, ~5 months old) were used as an early adult control. (B) Tibialis anterior (TA) muscle mass corrected for body mass in young control, and middle-aged control and 1-, 3- or 7-day denervated limbs. (C) TA mass represented as fold of age-matched control. Values are means ± SEM. Main effects of den are represented on graph. *p< 0.05, post-hoc significance. N=12/young control and middle-aged control, N=4/denervation time point.