Research Paper Volume 14, Issue 22 pp 8900—8913

Denervation induces mitochondrial decline and exacerbates lysosome dysfunction in middle-aged mice


Figure 4. Proteins related to mitochondrial dynamics and mitophagy in young and middle-aged control and denervated skeletal muscle. (A) Representative western blots for Opa1, Drp1, Bnip3 and Parkin proteins in skeletal muscle samples. Quantification of (B) Opa1 protein; (C) Drp1 protein; (D) Opa1/Drp1 protein; (E) Parkin protein; and (F) Bnip3 protein. *p<0.05, **p<0.01, *** p<0.001 t-test between young and middle-aged control. N=12/young and middle-aged control, N=4/denervation time point.