Research Paper Volume 14, Issue 21 pp 8839—8855
lncRNA HHIP-AS1/HHIP modulates osteogenic differentiation of BM-MSCs by regulating Hedgehog signaling pathway
Figure 7. The schematic diagram of lncRNA HHIP-AS1/HHIP modulating osteogenic differentiation of BM-MSCs. lncRNA HHIP-AS1 bound to HHIP mRNA through complementary base pairing. This interaction increased ELAVL1 binding to HHIP mRNA and thus improved the mRNA stability and expression. HHIP protein can binds to SHH, which suppresses the activation of SMO by SHH. As the result, osteogenic differentiation of BM-MSCs induced by Hedgehog signal is suppressed.