Research Paper Volume 14, Issue 23 pp 9599—9616

Identification and validation of ubiquitin-proteasome system related genes as a prognostic signature for papillary renal cell carcinoma


Figure 6. Hub-related gene enrichment analysis. (A) The heatmap shows the Pearson correlation between the risk genes in PRCC. (B) The top 20 genes that correlated with those risk genes were obtained through the STRING tool. (C) GO (BP, CC, and MF) and KEGG pathway analysis of 10 hub genes and 20 interacted genes. (D) Net-plot of these gene enrichment analyses. “Red” represents the positive correlation and “Blue” represents the negative correlation. Abbreviations: GO: gene ontology; BP: biological process; CC: cellular component; MF: molecular function; KEGG: Kyoto encyclopedia of genes and genomes. *P < 0.05, **P < 0.01, ***P < 0.001.