Research Paper Volume 14, Issue 23 pp 9599—9616

Identification and validation of ubiquitin-proteasome system related genes as a prognostic signature for papillary renal cell carcinoma


Figure 7. Correlation between risk genes expression and clinicopathological parameter of PRCC. (A) Boxplot showing that superior expression of UBE2C, DCB2, UBE2O, SIAH1, SKP2, and CDC20 were significantly related to advanced pathological grades, whereas low expression of CBLC and PRKN was significantly correlated with severe pathological features. (B) Boxplot showing that the expression of UBE2C, DCB2, SKP2, UBE2O, SIAH1, and CDC20 mRNA in PRCC samples are significantly correlated with severe pathologic staging and the expression of CBLC and PRKN at mRNA level were lower in patients with stage 4. *P < 0.05, **P < 0.01, ***P < 0.001, Abbreviations: ns: non-significance.