Research Paper Volume 14, Issue 22 pp 9056—9089

Circadian rhythm-related factors of PER and CRY family genes function as novel therapeutic targets and prognostic biomarkers in lung adenocarcinoma


Figure 12. Relationships of expressions and copy number alteration (CNA) effects of PER (period) and CRY (cryptochrome) family members with immune infiltration-related cells, including B cells, cluster of differentiation 4-positive (CD4+) T cells, CD8+ T cells, macrophages, neutrophils, and dendritic cells (using TIMER). (A) Correlations of immune infiltration-related cells and expressions of PER1, PER2, PER3, CRY1, and CRY2. (B) CNAs of different circadian factors affect infiltration levels in LUAD. * p<0.05, ** p<0.01, and *** p<0.001, compared to arm-level deletions, the diploid/normal group, and arm-level gain.