Research Paper Volume 14, Issue 22 pp 9103—9127

Exploring the mechanisms underlying the therapeutic effect of the Radix Bupleuri-Rhizoma Cyperi herb pair on hepatocellular carcinoma using multilevel data integration and molecular docking


Figure 8. Prognostic analysis of cell cycle-related genes and establishment of a prognostic model. (A) Heatmap of the expression patterns of 6 cell cycle-related genes in 18 pairs of adjacent non-tumor liver tissues and HCC tissues. (B) Forest plot of the univariate Cox analysis of 6 cell cycle-related genes. (C) Correlation network of 6 cell cycle-related genes. (D) LASSO coefficient profiles of 6 cell cycle-related genes. (E) Cross-validation for tuning parameter selection in the LASSO regression analysis. (F) The distribution of risk scores, gene expression levels, and survival status of patients with LIHC in the training cohort. (G) Kaplan–Meier curves of the OS of all patients with LIHC in TCGA cohort based on the risk score. (H) Time-dependent ROC curve analysis of the prognostic model (1, 3, and 5 years).