Research Paper Volume 14, Issue 22 pp 9103—9127
Exploring the mechanisms underlying the therapeutic effect of the Radix Bupleuri-Rhizoma Cyperi herb pair on hepatocellular carcinoma using multilevel data integration and molecular docking
Figure 9. Correlation analysis of the expression of four cell cycle-related genes with clinical features and immune cell infiltration in patients with LIHC. (A) The differential expression of CCNB1, CDK4, CDKN2A, and CHEK1 between normal and tumor tissues. (B) CCNB1, CDK4, CDKN2A, and CHEK1 mRNA expression in normal individuals or individuals with different pathologic stages (stage I and II, and stage III and IV). (C) Differences expression of CCNB1, CDK4, CDKN2A, and CHEK1 mRNA in patients with different types of vascular invasion. (D) Kaplan-Meier curves of OS for different cell cycle-related genes. (E) Kaplan-Meier curves of DSS for different cell cycle-related genes. (F) Correlation analysis between four cell cycle-related genes and infiltration levels of different immune cells estimated using TIMER, EPIC, XCELL, CIBERSORT, and QUANTISEQ. *, **, and *** represent P < 0.05, P < 0.01, and P < 0.001, respectively.