Research Paper Volume 14, Issue 22 pp 8914—8926

Glutaminase inhibitors rejuvenate human skin via clearance of senescent cells: a study using a mouse/human chimeric model


Figure 3. Removal of SA-β-Gal-positive cells from human skin grafts by BPTES treatment. (A) Skin tissue stained with SA-β-Gal (blue); Bar = 100 μm. (B) Quantification of SA-β-Gal-positive cells in the dermis, excluding the area of the skin appendage. The number of positive cells was counted in high magnification field of view (HPF) (≥5 fields of view per sample). Graphs show the mean ± SEM of three independent experiments. *p < 0.05.