Research Paper Volume 14, Issue 22 pp 8914—8926

Glutaminase inhibitors rejuvenate human skin via clearance of senescent cells: a study using a mouse/human chimeric model


Figure 6. Senescent cell elimination drug BPTES improves the skin senescence phenotype of transplanted aged human skin. (A) Evaluation of skin collagen deposition using representative images of MT and H&E staining. (B) Quantification of collagen density in skin sections from the indicated mice. Data represent three or more random sites in each section (n = 3–5). (C) Relative mRNA levels of Col1a1 in the skin from aged mice. *p < 0.05, Mann–Whitney U test; bar = 100 μm.