Research Paper Volume 14, Issue 24 pp 10009—10026
Role of m6A modification and novel circ_0066715/ miR-486-5p/ ETS1 axis in rheumatoid arthritis macrophage polarization progression
Figure 1. Screening of circ_0066715 and its role in RA. (A) Heat map of circRNA differential expression in PBMC of RA patients. (n=3). (B) Volcano plot of circRNA differential expression in PBMC of RA patients. (n=3). (C) Comparison of differential expression of three circRNAs in RA patients. **P<0.01, vs circ_0066715-HC. *P<0.05, vs circ_0017251-HC. (n=15, paired t-test). (D) Circ_0066715 feature verification in RA-FLS cells. ***P < 0.001,**P < 0.01,*P < 0.05.(n=3, paired t-test). (E) Correlation analysis between circ_0066715 and clinical indicators of in RA patients. (n=15, Spearman rank correlation analysis). (F) ROC curve of circ_0066715 and disease in RA patients. AUC=0.823, P=0.011, 95% CI: 0.**P < 0.01623~1.000.(n=30, ROC curve analysis).