Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

Volume 14, Issue 24

31 December, 2022
pp 9775—10216

About the Cover

The cover features Figure 1 "A schematic diagram of potential APOE-related mechanism of Alzheimer’s disease (AD), from Kulminski et al.

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Editorials

Leveraging pathway analysis in a human skin model of healthy aging

Dimitrios Tsitsipatis, Myriam Gorospe, Allison B. Herman,

https://doi.org/10.18632/aging.204456 pp 9775—9776

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Are aged pTreg cells “the more the better”?

Weikan Wang, Rachel Thomas, Dong-Ming Su,

https://doi.org/10.18632/aging.204454 pp 9777—9778

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Single short reprogramming early in life increases healthspan

Ollivier Milhavet, Jean-Marc Lemaitre,

https://doi.org/10.18632/aging.204457 pp 9779—9781

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Research Papers

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers

Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, for the Alzheimer’s Disease Neuroimaging Initiative,

https://doi.org/10.18632/aging.204384 pp 9782—9804

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12-year evolution of multimorbidity patterns among older adults based on Hidden Markov Models

Albert Roso-Llorach, Davide L. Vetrano, Caterina Trevisan, Sergio Fernández, Marina Guisado-Clavero, Lucía A. Carrasco-Ribelles, Laura Fratiglioni, Concepción Violán, Amaia Calderón-Larrañaga,

https://doi.org/10.18632/aging.204395 pp 9805—9817

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Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV

Mikki Schantell, Brittany K. Taylor, Rachel K. Spooner, Pamela E. May, Jennifer O’Neill, Brenda M. Morsey, Tina Wang, Trey Ideker, Sara H. Bares, Howard S. Fox, Tony W. Wilson,

https://doi.org/10.18632/aging.204437 pp 9818—9831

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Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs

Dimitrios Tsitsipatis, Krystyna Mazan-Mamczarz, Ying Si, Allison B. Herman, Jen-Hao Yang, Abhishek Guha, Yulan Piao, Jinshui Fan, Jennifer L. Martindale, Rachel Munk, Xiaoling Yang, Supriyo De, Brijesh K. Singh, Ritchie Ho, Myriam Gorospe, Peter H. King,

https://doi.org/10.18632/aging.204450 pp 9832—9859

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C-C motif chemokine ligand 2 promotes myogenesis of myoblasts via the AKT-mTOR pathway

Mi Kyung Kwak, Eun Suk Ha, Jiwoo Lee, Yun Mi Choi, Beom-Jun Kim, Eun-Gyoung Hong,

https://doi.org/10.18632/aging.204451 pp 9860—9876

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SOX2-high cancer cells exhibit an aggressive phenotype, with increases in stemness, proliferation and invasion, as well as higher metabolic activity and ATP production

Marta Mauro-Lizcano, Federica Sotgia, Michael P. Lisanti,

https://doi.org/10.18632/aging.204452 pp 9877—9889

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Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF

Jia Zhao, Wei Zhang, Shentong Wang, Zinan Li, Yuqi Huang, Longyun Li,

https://doi.org/10.18632/aging.204398 pp 9890—9907

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Early life exercise training and inhibition of apoLpp mRNA expression to improve age-related arrhythmias and prolong the average lifespan in Drosophila melanogaster

Meng Ding, Qiu Fang Li, Tian Hang Peng, Tong Quan Wang, Han Hui Yan, Chao Tang, Xiao Ya Wang, Yin Guo, Lan Zheng,

https://doi.org/10.18632/aging.204422 pp 9908—9923

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A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression

Siqin Chen, Yang Yu, Yixiao Yuan, Xi Chen, Fan Zhou, Yongwu Li, Ping Wang, Xiulin Jiang, Sha Tian, Wenjun Ren,

https://doi.org/10.18632/aging.204426 pp 9924—9941

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Qi Ling decoction enhances abiraterone treatment via suppression of autophagy in castration resistant prostate cancer

Yigeng Feng, Hongwen Cao, Zixi Song, Lei Chen, Dan Wang, Renjie Gao,

https://doi.org/10.18632/aging.204427 pp 9942—9950

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A nomogram for predicting prognosis of multiple myeloma patients based on a ubiquitin-proteasome gene signature

Dexiang Ji, Yong Liu, Wenjie Sun, Qing Shi, Guoan Chen, Zhiwang Song, Yanxia Jiang,

https://doi.org/10.18632/aging.204432 pp 9951—9968

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Fatty acid metabolism-related signature predicts survival in patients with clear cell renal carcinoma

Rongjiang Wang, Junwen Shen, Yu Chen, Jianguo Gao, Jianxiang Yao,

https://doi.org/10.18632/aging.204433 pp 9969—9979

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The prognostic value of NLRP1/NLRP3 and its relationship with immune infiltration in human gastric cancer

Ping Wang, Yulan Gu, Jianke Yang, Jiamin Qiu, Yeqiong Xu, Zengxiang Xu, Jiguang Gao, Chuandan Wan,

https://doi.org/10.18632/aging.204438 pp 9980—10008

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Role of m6A modification and novel circ_0066715/ miR-486-5p/ ETS1 axis in rheumatoid arthritis macrophage polarization progression

Lei Wan, Jian Liu, Chuanbing Huang, Ziheng Zhu, Fangze Li, Guanghan Sun, Kun Wang, Shu Li, Ximeng Ma, Xi Chen, Wang Yuan,

https://doi.org/10.18632/aging.204439 pp 10009—10026

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High MCM8 expression correlates with unfavorable prognosis and induces immune cell infiltration in hepatocellular carcinoma

Meng Yu, Huaxiang Wang, Hongyang Xu, Yuhang Lv, Qingsong Li,

https://doi.org/10.18632/aging.204440 pp 10027—10049

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SGOL2 promotes prostate cancer progression by inhibiting RAB1A ubiquitination

Tingting Lv, Dongwei He, Xiaokuan Zhang, Xiaojin Guo, Zijie Li, Aili Zhang, Bo Fan, Zhiyu Wang,

https://doi.org/10.18632/aging.204443 pp 10050—10066

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Starvation-induced long non-coding RNAs are significant for prognosis evaluation of bladder cancer

Chunlin Zhang, Xuesong Bai, Xiang Peng, Wei Shi, Yang Li, Guo Chen, Haitao Yu, Zhenwei Feng, Yuanzhong Deng,

https://doi.org/10.18632/aging.204444 pp 10067—10080

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SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells

Zhipeng Tang, Pei Zhao, Wanxing Zhang, Qian Zhang, Ming Zhao, He Tan,

https://doi.org/10.18632/aging.204446 pp 10081—10092

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Development of a 7-miRNA prognostic signature for patients with bladder cancer

Yingjie Xv, Ming Qiu, Zhaojun Liu, Mingzhao Xiao, Fen Wang,

https://doi.org/10.18632/aging.204447 pp 10093—10106

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A comprehensive analysis of the FOX family for predicting kidney renal clear cell carcinoma prognosis and the oncogenic role of FOXG1

Wenjie Yang, Hualin Chen, Lin Ma, Jie Dong, Mengchao Wei, Xiaoqiang Xue, Yingjie Li, Zhaoheng Jin, Weifeng Xu, Zhigang Ji,

https://doi.org/10.18632/aging.204448 pp 10107—10124

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Exosomes derived from human umbilical cord mesenchymal stem cells promote osteogenesis through the AKT signaling pathway in postmenopausal osteoporosis

Shi-Wei Ren, Guang-Qing Cao, Qing-Run Zhu, Min-Gang He, Fang Wu, Su-Mei Kong, Zhao-Yan Zhang, Qiang Wang, Feng Wang,

https://doi.org/10.18632/aging.204453 pp 10125—10136

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Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

Xiang-Ke Chen, Chen Zheng, Stephen Heung-Sang Wong, Alvin Chun-Hang Ma,

https://doi.org/10.18632/aging.204458 pp 10137—10152

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Sevoflurane postconditioning ameliorates cerebral ischemia-reperfusion injury in rats via TLR4/MyD88/TRAF6 signaling pathway

Zijun Zhao, Yishuai Li, Fei Chi, Li Ma, Yanan Li, Zhiyong Hou, Qiujun Wang,

https://doi.org/10.18632/aging.204461 pp 10153—10170

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The tumor microenvironment in gastrointestinal adenocarcinomas revealed a prognostic and immunotherapeutic biomarker

Yong Zhang, Lu Li, Feifei Chu, Lei Zhang, Li Zhang, Huili Wu, Kunkun Li,

https://doi.org/10.18632/aging.204463 pp 10171—10216

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