Research Paper Volume 14, Issue 24 pp 10027—10049
High MCM8 expression correlates with unfavorable prognosis and induces immune cell infiltration in hepatocellular carcinoma
Figure 5. MCM8 alteration was associated with worse survival in HCC patients. (A) 60% of the queried patients have detected alteration of MCM8 in the cBioPortal database. (B) A mutational hotspot of H161Q/Missense was detected in 29 HCC patients. (C) Dysregulation of MCM8 mRNA expression correlated with copy number alterations in HCC. (D, E) Patients with MCM8 alteration have poorer overall survival probability (D) and disease-free survival probability (E) than patients without genetic alterations. (F) Mutation status of TP53 (a), ABCB5 (b), CUBN (c) and RB1 (d) were correlated with dysregulation of MCM8 mRNA expression in HCC.