Research Paper Volume 14, Issue 24 pp 10027—10049
High MCM8 expression correlates with unfavorable prognosis and induces immune cell infiltration in hepatocellular carcinoma
Figure 7. Analysis of MCM8 co-expressed genes in HCC. (A) 69 overlapping co-expressed genes of MCM8 were identified from the GEPIA, LinkedOmics and cBioPortal database. (B) The PPI network showed that the MCM4, MCM6, MCM10, CDC7 and PRIM1 protein directly interacted with MCM8. (C) MCM4 (a), MCM6 (b), MCM10 (c), CDC7 (d) and PRIM1 (e) mRNA were overexpressed in HCC. (D) Correlation of MCM8 mRNA levels with MCM4 (a), MCM6 (b), MCM10 (c), CDC7 (d) and PRIM1 (e) mRNA levels. (E) Higher MCM4 (a), MCM6 (b), MCM10 (c), CDC7 (d) and PRIM1 (e) mRNA expression predicted poorer overall survival times of HCC patients. ***P<0.001.