Research Paper Volume 14, Issue 24 pp 10081—10092
SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells
Figure 5. The roles of SALL4 on the metastatic and invasive ability of hepatoma cells in vitro. (A) Migration experiment was performed to detect the number of migration cells in HepG2 and SMMC-7721 HCC cells, the SALL4 mimic increased the migrated numbers and SALL4 inhibitor decreased migrated cell numbers; (B) Invasion experiment was used to detect the number of HepG2 and SMMC-7721 HCC cells crossing the basement membrane, the SALL4 mimic increased the numbers of invaded cells and SALL4 inhibitor suppressed the numbers of invaded cells in both HepG2 and SMMC-7721 cells. n = 3/group, t test between two groups, and by one-way analysis of variance among groups. *p < 0.05, **p < 0.01 vs. NC group.