Editorial Volume 14, Issue 24 pp 9777—9778

Figure 1. Illustration of the participation of aged excessive pTreg cells in an age-related neuroinflammatory disorder. (A) Aged mice have accumulated peripheral Treg cells but display more severe EAE symptoms, due to over-suppression of IFNγ producing leukocytes. (B) Accumulated peripheral Tregs impair immune cells, including specific Treg cells, the infiltration into the CNS (red “X”), resulting in imbalanced CNS Teff versus Treg cells. (C) Transient inhibition of accumulated and excessive peripheral Tregs (right top red “Xs”). (D) The CNS-infiltration pathway is more permeable when the peripheral Treg cells are transiently inhibited, and more CNS-Treg cells are detected and the EAE disease is ameliorated in the aged inflamed CNS.