Editorial Volume 14, Issue 24 pp 9775—9776

Figure 1. Leveraging Pathway Analysis in a Human Skin Model of Healthy Aging. Primary fibroblast cultures were established from skin biopsies of individuals within the GESTALT study of healthy aging (NIA, NIH), and their proteomes were analyzed by mass spectrometry. Although the expression levels of individual proteins varied across donors within the same age group, the activities of pathways in which these proteins participate were highly consistent. Hence, we propose that interventions aimed at restoring the function of pathways (instead of the function of individual proteins) may be more effective in preventing age-associated declines in older tissues.