Research Paper Volume 15, Issue 3 pp 705—717

miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1

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Figure 2. VDAC1 promotes the proliferation, migration and invasion of breast cancer. The VDAC1 overexpression plasmid plvx-VDAC1 or blank plasmid plvx-Con was transfected into BT549 and MCF-7 cells. (A, B) Cell proliferation was detected with CCK8 assay (A) and EDU assay (B). (C, D) Transwell assay was used to detect cell migration and invasion ability. The data are presented as the mean ± S.D. *P < 0.05, **P < 0.01.