Research Paper Volume 15, Issue 18 pp 9341—9357

Palmitic acid promotes human retinal pigment epithelial cells migration by upregulating miR-222 expression and inhibiting NUMB


Figure 6. A novel palmitic acid-miR-222-NUMB pathway in regulating human RPEC migration. PA promotes ARPE-19 cell migration in a dose-dependent manner when administrated at a concentration no more than 200 μM. PA induces miR-222 expression and promotes the EMT of ARPE-19 cells. NUMB is one downstream target of miR-222. PA treatment suppresses NUMB expression, and NUMB knockdown alone in ARPE-19 cells also enhances RPEC migration and EMT.