Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 15, Issue 18

30 September, 2023
pp 9233—9891

About the Cover

The cover features Figure 2 "Comprehensive transcriptional analysis of senescent corneal and conjunctival epithelial cells" from Kitazawa et al.

Explore This Issue

Editorials

Heart rate variability: a predictor of cognitive decline

Paola Nicolini, Tiziano Lucchi, Marco Vicenzi,

https://doi.org/10.18632/aging.204715 pp 9233—9234

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Beyond amyloid: altered gene function in neurodegenerative diseases

Metin Yesiltepe, Tao Yin, Luciano D’Adamio,

https://doi.org/10.18632/aging.204717 pp 9235—9237

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Priority Research Paper

Gene expression signatures of human senescent corneal and conjunctival epithelial cells

Koji Kitazawa, Akifumi Matsumoto, Kohsaku Numa, Yasufumi Tomioka, Zhixin A. Zhang, Yohei Yamashita, Chie Sotozono, Pierre-Yves Desprez, Judith Campisi,

https://doi.org/10.18632/aging.205113 pp 9238—9249

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Research Papers

High-throughput single-cell profiling of B cell responses following inactivated influenza vaccination in young and older adults

Meng Wang, Ruoyi Jiang, Subhasis Mohanty, Hailong Meng, Albert C. Shaw, Steven H. Kleinstein,

https://doi.org/10.18632/aging.204778 pp 9250—9274

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Effect of cognitive reserve on the association between slow wave sleep and cognition in community-dwelling older adults

Valentin Ourry, Stéphane Rehel, Claire André, Alison Mary, Léo Paly, Marion Delarue, Florence Requier, Anne Hendy, Fabienne Collette, Natalie L. Marchant, Francesca Felisatti, Cassandre Palix, Denis Vivien, Vincent de la Sayette, Gaël Chételat, Julie Gonneaud, Géraldine Rauchs, the Medit-Ageing Research Group,

https://doi.org/10.18632/aging.204943 pp 9275—9292

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Biomedical generative pre-trained based transformer language model for age-related disease target discovery

Diana Zagirova, Stefan Pushkov, Geoffrey Ho Duen Leung, Bonnie Hei Man Liu, Anatoly Urban, Denis Sidorenko, Aleksandr Kalashnikov, Ekaterina Kozlova, Vladimir Naumov, Frank W. Pun, Ivan V. Ozerov, Alex Aliper, Alex Zhavoronkov,

https://doi.org/10.18632/aging.205055 pp 9293—9309

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Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study

May A. Beydoun, Hind A. Beydoun, Marie T. Fanelli-Kuczmarski, Jordan Weiss, Michael F. Georgescu, Osorio Meirelles, Donald M. Lyall, Michele K. Evans, Alan B. Zonderman,

https://doi.org/10.18632/aging.205058 pp 9310—9340

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Palmitic acid promotes human retinal pigment epithelial cells migration by upregulating miR-222 expression and inhibiting NUMB

Fengzhi Li, Chunling Lei, Ke Gong, Shuwei Bai, Lianyi Sun,

https://doi.org/10.18632/aging.204647 pp 9341—9357

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Identification of senescence-related lncRNA prognostic index correlating with prognosis and radiosensitivity in prostate cancer patients

Dechao Feng, Li Li, Xu Shi, Weizhen Zhu, Jie Wang, Ruicheng Wu, Dengxiong Li, Wuran Wei, Ping Han,

https://doi.org/10.18632/aging.204888 pp 9358—9376

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Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B

Wenpeng Cao, Xiaozhong Chen, Chaolun Xiao, Dengxiao Lin, Yumei Li, Shipeng Luo, Zhirui Zeng, Baofei Sun, Shan Lei,

https://doi.org/10.18632/aging.204940 pp 9377—9390

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Screening diagnostic markers of osteoporosis based on ferroptosis of osteoblast and osteoclast

Zhihai Cao, Yuan Xue, Jiaqian Wang,

https://doi.org/10.18632/aging.204945 pp 9391—9407

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A cellular senescence-related genes model allows for prognosis and treatment stratification of cervical cancer: a bioinformatics analysis and external verification

Weiwei Yang, Lijuan An, Yanfei Li, Sumin Qian,

https://doi.org/10.18632/aging.204981 pp 9408—9425

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The mechanism of simultaneous intake of Jujuboside A and B in the regulation of sleep at the hypothalamic level

Wei Wang, Yi Wang, Hongyan Pei, Mingming Li, Aozhe Zhu, Rui Du, Gao Jun Peng,

https://doi.org/10.18632/aging.204995 pp 9426—9437

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Astragalus polysaccharide inhibits the development of urothelial carcinoma by activating AMPK signaling to induce BENC1-xCT complex formation

Guangquan Tong, Xiaowei Wang, Shuangfeng Chen, Yanyang Jin,

https://doi.org/10.18632/aging.205007 pp 9438—9452

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Environmental enrichment enhanced neurogenesis and behavioral recovery after stroke in aged rats

Ji Yan, Yan Liu, Fangda Zheng, Dan Lv, Di Jin,

https://doi.org/10.18632/aging.205010 pp 9453—9463

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Serum sirtuin1: a potential blood biomarker for early diagnosis of Alzheimer’s disease

Jia Wang, Fang Zhou, Chang-E Xiong, Gui-Ping Wang, Lin-Wanyue Chen, Yu-Tong Zhang, Shi-Ge Qi, Zhi-Hui Wang, Can Mei, Yu-Jia Xu, Jian-Bo Zhan, Jing Cheng,

https://doi.org/10.18632/aging.205015 pp 9464—9478

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Complement and coagulation cascades pathway-related signature as a predictor of immunotherapy in metastatic urothelial cancer

Zheng Gong, Yuming He, Xiao Mi, Chengcheng Li, Xiaoran Sun, Guoqiang Wang, Leo Li, Yusheng Han, Chunwei Xu, Wenxian Wang, Shangli Cai, Liang Wang, Zhongyuan Liu,

https://doi.org/10.18632/aging.205022 pp 9479—9498

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M2 macrophage-derived exosomal miR-486-5p influences the differentiation potential of bone marrow mesenchymal stem cells and osteoporosis

Jincheng Liu, Zhenqian Sun, Yunhao You, Lu Zhang, Dehui Hou, Guanghui Gu, Yunzhen Chen, Guangjun Jiao,

https://doi.org/10.18632/aging.205031 pp 9499—9520

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Construction of a novel cancer-associated fibroblast-related signature to predict clinical outcome and immune response in colon adenocarcinoma

Lei Zheng, Jiale Zhang, Yingquan Ye, Zhangpeng Shi, Yi Huang, Mengmeng Zhang, Zhongxuan Gui, Ping Li, Huanlong Qin, Weijie Sun, Mei Zhang,

https://doi.org/10.18632/aging.205032 pp 9521—9543

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Human umbilical cord mesenchymal stem cells-derived exosomes exert anti-inflammatory effects on osteoarthritis chondrocytes

Shichao Wang, Wenyue Jiang, Shuang Lv, Zhicheng Sun, Lihui Si, Jinxin Hu, Yang Yang, Dingbang Qiu, Xiaobin Liu, Siying Zhu, Lunhao Yang, Ling Qi, Guangfan Chi, Guiqing Wang, Pengdong Li, Baojian Liao,

https://doi.org/10.18632/aging.205034 pp 9544—9560

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Impact of liver metastases status on survival outcomes of first-line immunotherapy in extensive stage small cell lung cancer: a systematic review and meta-analysis

Yan Lin, Wei Jiang, Cui-Yun Su, Xin-Bin Pan,

https://doi.org/10.18632/aging.205035 pp 9561—9571

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Core fucosylation regulates alveolar epithelial cells senescence through activating of transforming growth factor-β pathway in pulmonary fibrosis

Yu Jiang, Zhongzhen Wang, Jinying Hu, Wei Wang, Na Zhang, Lili Gao,

https://doi.org/10.18632/aging.205036 pp 9572—9589

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YY1 is regulated by ALKBH5-mediated m6A modification and promotes autophagy and cancer progression through targeting ATG4B

Shijiang Wang, Jiangbo Nie, Kaiying Xu, Yangyang Liu, Weilai Tong, Anan Li, Wei Zuo, Zhili Liu, Feng Yang,

https://doi.org/10.18632/aging.205037 pp 9590—9613

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ALDOC promotes non-small cell lung cancer through affecting MYC-mediated UBE2N transcription and regulating Wnt/β-catenin pathway

Bin Shang, Fengjuan Lu, Shujuan Jiang, Mengmeng Xing, Xinyu Mao, Guanghai Yang, Hao Zhang,

https://doi.org/10.18632/aging.205038 pp 9614—9632

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A novel risk model of three gefitinib-related genes FBP1, SBK1 and AURKA is related to the immune microenvironment and is predicting prognosis of lung adenocarcinoma patients

Qiang Guo, Kai Li, Ni Jiang, Rui Zhou, Xin-Rui Rao, Chuang-Yan Wu,

https://doi.org/10.18632/aging.205040 pp 9633—9660

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Aberrant expression of AKR1B1 indicates poor prognosis and promotes gastric cancer progression by regulating the AKT-mTOR pathway

Luojie Liu, Lihua Zhu, Zhengwu Cheng, Yibin Sun, Yuqing Zhou, Jiwei Cao,

https://doi.org/10.18632/aging.205041 pp 9661—9675

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Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma

Ling Huang, Lifan Zhong, Ruxin Cheng, Limei Chang, Mingyan Qin, Huaping Liang, Zhongkai Liao,

https://doi.org/10.18632/aging.205042 pp 9676—9694

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Characterization of tumor microenvironment and sensitive chemotherapy drugs based on cuproptosis-related signatures in renal cell carcinoma

Jiefu Tang, Fan Yao, Zhiyong Yao, Xiao-Liang Xing,

https://doi.org/10.18632/aging.205043 pp 9695—9717

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Integrated single-cell and bulk RNA sequencing revealed the molecular characteristics and prognostic roles of neutrophils in pancreatic cancer

Biao Zhang, Jiaao Sun, Hewen Guan, Hui Guo, Bingqian Huang, Xu Chen, Feng Chen, Qihang Yuan,

https://doi.org/10.18632/aging.205044 pp 9718—9742

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NOTCH2 gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer

Wenjing Wang, Ruiqian Liu, Wei Liao, Landie Ji, Jie Mei, Dan Su,

https://doi.org/10.18632/aging.205045 pp 9743—9758

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Prognostic significance of CTNNB1 mutation in hepatocellular carcinoma: a systematic review and meta-analysis

Genlin Lu, Jian Lin, Guoqiang Song, Min Chen,

https://doi.org/10.18632/aging.205047 pp 9759—9778

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Pan-cancer analysis and experimental validation identify ndc1 as a potential immunological, prognostic and therapeutic biomarker in pancreatic cancer

Qian Shen, Junchen Li, Chuanlong Zhang, Xue Pan, Yi Li, Xiyuan Zhang, Ge’er En, Bo Pang,

https://doi.org/10.18632/aging.205048 pp 9779—9796

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Investigating the causal effect of Dickkopf-1 on coronary artery disease and ischemic stroke: a Mendelian randomization study

Peng-Fei Zheng, Jing-Jing Rong, Zhao-Fen Zheng, Zheng-Yu Liu, Hong-Wei Pan, Peng Liu,

https://doi.org/10.18632/aging.205050 pp 9797—9808

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The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1

Yao Li, Xue Meng, Yuqing Luo, Shuai Luo, Jin Li, Jiafei Zeng, Xiang Huang, Jinjing Wang,

https://doi.org/10.18632/aging.205051 pp 9809—9821

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Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma

Xiaonan Zhang, Jie Chen, Ming Zhang, Saisai Liu, Tao Wang, Tianyu Wu, Baiqing Li, Shidi Zhao, Hongtao Wang, Li Li, Chun Wang, Li Huang,

https://doi.org/10.18632/aging.205052 pp 9822—9841

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Prognosis and immunoinfiltration analysis of angiogene-related genes in grade 4 diffuse gliomas

Hui Liu, Zhirui Zeng, Peng Sun,

https://doi.org/10.18632/aging.205054 pp 9842—9857

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m5C methylation modification guides the prognostic value and immune landscapes in acute myeloid leukemia

Ya Liu, Yiying Chen, Maoping Cai, Yunguang Hong, Xiang Wu, Songyu Li,

https://doi.org/10.18632/aging.205059 pp 9858—9876

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Myeloid-specific knockout of SHP2 regulates PI3K/PLCγ signaling pathway to protect against early myocardial infarction injury

Menglin Sha, Hongxing Li, Bingyan Guo, Xiaoyong Geng,

https://doi.org/10.18632/aging.205096 pp 9877—9889

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Correction

Correction for: Klotho alleviates indoxyl sulfate-induced heart failure and kidney damage by promoting M2 macrophage polarization

Jing Lv, Jin Chen, Minjia Wang, Fei Yan,

https://doi.org/10.18632/aging.205114 pp 9890—9891

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