Research Paper Volume 15, Issue 8 pp 3107—3119
Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
Figure 2. Melatonin weakened the cell migration/invasion abilities of the UBUC cells. (A) The migration ability altered by melatonin in the UBUC cells was detected by a wound healing assay, and (B) the relative migrated area and migrated cell numbers were quantified at 24 and 48 hours. A transwell assay was used to evaluate the (C) migration and (D) invasion abilities of the UBUC cells with a melatonin treatment. The migrated and invaded cells that crossed the membrane were quantified and are depicted as bar plots. The bars represent mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.