Research Paper Advance Articles

Senescence and senotherapies in biliary atresia and biliary cirrhosis


Figure 3. Digital spatial whole transcriptomic analysis in BA livers. (A) Design of the analysis. (B) PCA of the dataset. (C) Enrichment analysis of published senescence gene lists between cholangiocytes subgroups. (D) Heatmaps of SASP genes obtained from two different published datasets in cholangiocytes and hepatocytes subgroups. BA: biliary atresia; Ctrl: control; FC: fold change; NES: normalized enrichment score; p-adj: adjusted p-value; PCA: principal component analysis; ROI: region of interest; SASP: senescence-associated secretory phenotype.