Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 15, Issue 11

15 June, 2023
pp 4566—5229

About the Cover

The cover features Figure 2 "COVID-19 patients present shorter telomeres in the alveolar type II cells than controls" from Martínez et al.

Explore This Issue

Editorials

Mutation and aging: news from the pool

Francesca Marcon, Margherita Bignami, Peter Karran,

https://doi.org/10.18632/aging.204779 pp 4566—4567

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Physical activity, interleukin-6 change, and gait speed

Francesco Panza, Carlo Custodero, Vincenzo Solfrizzi,

https://doi.org/10.18632/aging.204797 pp 4568—4570

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Automated frailty scores: towards clinical implementation

Jonathan K. L. Mak, Dorota Religa, Juulia Jylhävä,

https://doi.org/10.18632/aging.204815 pp 4571—4573

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Beyond the relationship between mitochondria and mobility in aging

Qu Tian, Luigi Ferrucci,

https://doi.org/10.18632/aging.204649 pp 4574—4575

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Research Papers

Senescence and senotherapies in biliary atresia and biliary cirrhosis

Giulia Jannone, Eliano Bonaccorsi Riani, Catherine de Magnée, Roberto Tambucci, Jonathan Evraerts, Joachim Ravau, Pamela Baldin, Caroline Bouzin, Axelle Loriot, Laurent Gatto, Anabelle Decottignies, Mustapha Najimi, Etienne Marc Sokal,

https://doi.org/10.18632/aging.204700 pp 4576—4599

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Impaired telomere pathway and fertility in Senescence-Accelerated Mice Prone 8 females with reproductive senescence

Alba M. Polonio, Marta Medrano, Lucía Chico-Sordo, Isabel Córdova-Oriz, Mauro Cozzolino, José Montans, Sonia Herraiz, Emre Seli, Antonio Pellicer, Juan A. García-Velasco, Elisa Varela,

https://doi.org/10.18632/aging.204731 pp 4600—4624

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Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer

Paula Martínez, Raúl Sánchez-Vazquez, Arpita Saha, Maria S. Rodriguez-Duque, Sara Naranjo-Gonzalo, Joy S. Osorio-Chavez, Ana V. Villar-Ramos, Maria A. Blasco,

https://doi.org/10.18632/aging.204755 pp 4625—4641

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Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice

Yutaro Kubota, Qinghong Han, Jose Reynoso, Yusuke Aoki, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Michael Bouvet, Takuya Tsunoda, Robert M. Hoffman,

https://doi.org/10.18632/aging.204783 pp 4642—4648

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Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery

Anatoly Urban, Denis Sidorenko, Diana Zagirova, Ekaterina Kozlova, Aleksandr Kalashnikov, Stefan Pushkov, Vladimir Naumov, Viktoria Sarkisova, Geoffrey Ho Duen Leung, Hoi Wing Leung, Frank W. Pun, Ivan V. Ozerov, Alex Aliper, Feng Ren, Alex Zhavoronkov,

https://doi.org/10.18632/aging.204788 pp 4649—4666

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Identification of novel genes associated with exercise and calorie restriction effects in skeletal muscle

Jae Sook Kang, Min Ju Kim, Eun-Soo Kwon, Kwang-Pyo Lee, Chuna Kim, Ki-Sun Kwon, Yong Ryoul Yang,

https://doi.org/10.18632/aging.204793 pp 4667—4684

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LAMP2A, and other chaperone-mediated autophagy related proteins, do not decline with age in genetically heterogeneous UM-HET3 mice

Katherine K. Zhang, Peichuan Zhang, Anagha Kodur, Ilkim Erturk, Calvin M. Burns, Cynthia Kenyon, Richard A. Miller, S. Joseph Endicott,

https://doi.org/10.18632/aging.204796 pp 4685—4698

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Pan-cancer analysis identifies LPCATs family as a prognostic biomarker and validation of LPCAT4/WNT/β-catenin/c-JUN/ACSL3 in hepatocellular carcinoma

Yaoyong Lu, Hongfeng Liang, Xiaoyin Li, Haiwen Chen, Changfu Yang,

https://doi.org/10.18632/aging.204723 pp 4699—4713

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KIF20A as a potential biomarker of renal and bladder cancers based on bioinformatics and experimental verification

Haoyuan Wang, Xiaopeng Ma, Sijie Li, Jianzhi Su, Bo Fan, Bin Liu, Xiaochen Ni,

https://doi.org/10.18632/aging.204736 pp 4714—4733

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miR-506-3p induces autophagy of renal tubular epithelial cells in sepsis through targeting PI3K pathway

Yun Dong, Xiaorui Han, Yong Yang, Hui Shi,

https://doi.org/10.18632/aging.204759 pp 4734—4745

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Calcium silicate-stimulated adipose-derived stem cells promote angiogenesis and improve skin wound healing

Mingming Wang, Hongyan Zhan, Jianhua Wang, Hua Song, Jianhua Sun, Gang Zhao,

https://doi.org/10.18632/aging.204760 pp 4746—4756

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Knocking down NSUN5 inhibits the development of clear cell renal cell carcinoma by inhibiting the p53 pathway

Lei Li, Mingyang Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen,

https://doi.org/10.18632/aging.204761 pp 4757—4773

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Visfatin upregulates VEGF-C expression and lymphangiogenesis in esophageal cancer by activating MEK1/2-ERK and NF-κB signaling

Chang-Lun Huang, David Achudhan, Po-I Liu, Yen-You Lin, Shan-Chi Liu, Jeng-Hung Guo, Chun-Lin Liu, Chih-Ying Wu, Shih-Wei Wang, Chih-Hsin Tang,

https://doi.org/10.18632/aging.204762 pp 4774—4793

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Identification of hub necroptosis-related lncRNAs for prognosis prediction of esophageal carcinoma

Zhengdong Luo, E Ding, Longchen Yu, Wenwu Wang, Qining Guo, Xinyang Li, Yifeng Wang, Tingting Li, Yi Zhang, Xin Zhang,

https://doi.org/10.18632/aging.204763 pp 4794—4819

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Construction and validation of an oxidative-stress-related risk model for predicting the prognosis of osteosarcoma

Hanning Wang, Juntan Li, Xu Li,

https://doi.org/10.18632/aging.204764 pp 4820—4843

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A novel predictive model based on inflammatory response-related genes for predicting endometrial cancer prognosis and its experimental validation

Yuting Wang, Bo Wang, Xiaoxin Ma,

https://doi.org/10.18632/aging.204767 pp 4844—4860

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Isoorientin ameliorates H₂O₂-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways

Tiehan Cui, Yun Lan, Yuying Lu, Fei Yu, Suai Lin, Yizhe Fu, Jiaxuan Qiu, Guangliang Niu,

https://doi.org/10.18632/aging.204768 pp 4861—4874

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Co-delivery of EGCG and melittin with self-assembled fluoro-nanoparticles for enhanced cancer therapy

Meiling Sun, Yue Wu, Zheyu Zhou, Siyuan Liu, Shuai Mao, Guoqiang Li,

https://doi.org/10.18632/aging.204769 pp 4875—4888

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Immune landscape and prognostic immune-related signature in KRAS-mutated lung adenocarcinoma

Xinyi Peng, Zhenqi Xia, Yong Guo, Yan Li,

https://doi.org/10.18632/aging.204770 pp 4889—4905

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A spliceosome-associated gene signature aids in predicting prognosis and tumor microenvironment of hepatocellular carcinoma

Huaxiang Wang, Ruling Wang, Jian Fang,

https://doi.org/10.18632/aging.204765 pp 4906—4925

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The potential of FCRL genes as targets for cancer treatment: insights from bioinformatics and immunology

Xiao Liang, Lei Du, Yuchao Fan,

https://doi.org/10.18632/aging.204766 pp 4926—4948

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PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion

Ying Fu, Yuan Sui, Yuming Zhao, Jianzhuo Jiang, Xueyuan Wang, Jiarui Cui, Xueqi Fu, Shu Xing, Zhizhuang Joe Zhao,

https://doi.org/10.18632/aging.204771 pp 4949—4962

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FDX1 serves as a prognostic biomarker and promotes glioma progression by regulating the immune response

Guangying Zhang, Liangfang Shen, Zhanzhan Li, Yajie Zhao,

https://doi.org/10.18632/aging.204772 pp 4963—4985

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Development of cancer-associated fibroblast-related gene signature for predicting the survival and immunotherapy response in lung adenocarcinoma

Yong Zhang, Fuyi Cheng, Jinhu Ma, Gang Shi, Hongxin Deng,

https://doi.org/10.18632/aging.204774 pp 4986—5006

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Machine learning and single cell RNA sequencing analysis identifies regeneration-related hepatocytes and highlights a Birc5-related model for identifying cell proliferative ability

Yuan Du, Shuqin Jian, Xicheng Wang, Chao Yang, Hua Qiu, Kang Fang, Yehong Yan, Jun Shi, Jianfeng Li,

https://doi.org/10.18632/aging.204775 pp 5007—5031

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CLDN5 identified as a biomarker for metastasis and immune infiltration in gastric cancer via pan-cancer analysis

Lu Han, De-Jun Cui, Bo Huang, Qian Yang, Tao Huang, Guo-Yuan Lin, Shao-Jie Chen,

https://doi.org/10.18632/aging.204776 pp 5032—5051

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Regulation of endothelial ferroptosis by SESN1 in atherosclerosis and its related mechanism

Feng Gao, Bin Zhang, Zhanfa Sun, Yuan Gao, Chunyi Liu, Xueyong Dou, Haokun Tong, Rui Wang,

https://doi.org/10.18632/aging.204777 pp 5052—5065

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Efficacy of first-line tyrosine kinase inhibitor between unresectable stage III and stage IV EGFR-mutated non-small cell lung cancer patients

Yang Liu, Huan-Wei Liang, Xin-Bin Pan,

https://doi.org/10.18632/aging.204781 pp 5066—5074

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The role of molecular subtypes and immune infiltration characteristics based on disulfidptosis-associated genes in lung adenocarcinoma

Cui Qi, Jianmin Ma, Jinjin Sun, Xiaolin Wu, Jian Ding,

https://doi.org/10.18632/aging.204782 pp 5075—5095

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Pan-cancer analysis of Homeobox B9 as a predictor for prognosis and immunotherapy in human tumors

Qingdong Jin, Li Xu, Jun Wang, Junling Lin, Huang Lin,

https://doi.org/10.18632/aging.204785 pp 5096—5124

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Network pharmacology-based research on the effect of angelicin on osteosarcoma and the underlying mechanism

Yafang Zhang, Junqiang Wei, Lingwei Kong, Mingze Song, Yange Zhang, Xiangyu Xiao, Haiying Cao, Zhehong Li, Ning Yang, Yu Jin,

https://doi.org/10.18632/aging.204786 pp 5125—5143

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Network medicine framework identified drug-repurposing opportunities of pharmaco-active compounds of Angelica acutiloba (Siebold & Zucc.) Kitag. for skin aging

Jiaxin Mo, Zunjiang Li, Hankun Chen, Zhongyu Lu, Banghan Ding, Xiaohong Yuan, Yuan Liu, Wei Zhu,

https://doi.org/10.18632/aging.204789 pp 5144—5163

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Identification of a novel MSI-related ceRNA network for predicting the prognosis and immunotherapy response of gastric cancer

Lei Zhang, Lu Cao, Jinqiang Liu, Lili Duan, Wei Zhou, Ting Li, Lei Guan, Xiaoming Wu, Huqin Zhang,

https://doi.org/10.18632/aging.204794 pp 5164—5189

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Identification of neoantigens and immunological subtypes in clear cell renal cell carcinoma for mRNA vaccine development and patient selection

Daoqi Zhu, Jiabin Yang, Minyi Zhang, Zhongxiao Han, Meng Shao, Qin Fan, Yun Ma, Dandan Xie, Wei Xiao,

https://doi.org/10.18632/aging.204798 pp 5190—5214

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PUS1 is a novel biomarker for evaluating malignancy of human renal cell carcinoma

Lin Li, Chongying Zhu, Shouying Xu, Qiang Xu, Da Xu, Sishun Gan, Xingang Cui, Chao Tang,

https://doi.org/10.18632/aging.204799 pp 5215—5227

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Retraction

Retraction: Long noncoding RNA VPS9D1-AS1 augments the malignant phenotype of non-small cell lung cancer by sponging microRNA-532-3p and thereby enhancing HMGA2 expression

Xiao Han, Tianren Huang, Junqing Han,

https://doi.org/10.18632/aging.204829 pp 5228—5229

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