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Research Paper|Volume 15, Issue 11|pp 5144—5163

Network medicine framework identified drug-repurposing opportunities of pharmaco-active compounds of Angelica acutiloba (Siebold & Zucc.) Kitag. for skin aging

Jiaxin Mo1, Zunjiang Li1, Hankun Chen3, Zhongyu Lu1, Banghan Ding1,2, Xiaohong Yuan2, Yuan Liu4, Wei Zhu2
  • 1The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou Province 510006, China
  • 2Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou Province 510120, China
  • 3Guangzhou Qinglan Biotechnology Co. Ltd., Guangzhou Province 515000, China
  • 4Guangzhou Huamiao Biotechnology Research Institute Co. Ltd., Guangzhou Province 510000, China
* Co-first authors
Received: February 6, 2023Accepted: May 15, 2023Published: June 12, 2023
https://doi.org/10.18632/aging.204789

Copyright: © 2023 Mo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Increasing incidence of skin aging has highlighted the importance of identifying effective drugs with repurposed opportunities for skin aging. We aimed to identify pharmaco-active compounds with drug-repurposing opportunities for skin aging from Angelica acutiloba (Siebold & Zucc.) Kitag. (AAK). The proximity of network medicine framework (NMF) firstly identified 8 key AAK compounds with repurposed opportunities for skin aging, which may exert by regulating 29 differentially expressed genes (DGEs) of skin aging, including 13 up-regulated targets and 16 down-regulated targets. Connectivity MAP (cMAP) analysis revealed 8 key compounds were involved in regulating the process of cell proliferation and apoptosis, mitochondrial energy metabolism and oxidative stress of skin aging. Molecular docking analysis showed that 8 key compounds had a high docked ability with AR, BCHE, HPGD and PI3, which were identified as specific biomarker for the diagnosis of skin aging. Finally, the mechanisms of these key compounds were predicted to be involved in inhibiting autophagy pathway and activating Phospholipase D signaling pathway. In conclusion, this study firstly elucidated the drug-repurposing opportunities of AAK compounds for skin aging, providing a theoretical reference for identifying repurposing drugs from Chinese medicine and new insights for our future research.