Research Paper Volume 15, Issue 10 pp 4533—4559

Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers


Figure 1. Expression level and phosphorylation of PFKFB3 in pan-cancer. (A) The expression status of the PFKFB3 gene in different cancers was analyzed via TIMER2. *P < 0.05; **P < 0.01; ***P < 0.001. (B) The expression of the PFKFB3 gene was studied according to the pathological stage (stage I–IV) of the different TCGA cancers, including CESC, THCA, PAAD, TGCT, and OV. (C) We analyzed the expression level of PFKFB3 protein in tumor and non-tumor tissues of colon cancer, UCEC, LUAD, ovarian cancer, KIRC, and breast cancer by the CPTAC dataset. **P < 0.01, ***P < 0.001. (D) We analyzed the phosphorylation level of PFKFB3 (S22, S461, and S441 sites) between primary tumor tissue and non-tumor tissues via the UALCAN. **P < 0.01, ***P < 0.001.