Research Paper Volume 15, Issue 11 pp 4875—4888

Co-delivery of EGCG and melittin with self-assembled fluoro-nanoparticles for enhanced cancer therapy


Figure 2. Biology functions of FEGCG@MPI NPs in vitro. (AC) CCK-8 assays were used to detect the viability of Hepatoma cells (Hep 3B cell) after treatment with various concentrations of FEGCG, MPI and FEGCG@MPI NPs separately. (D, E) Apoptosis of Hep3B cells after PBS, FEGCG, MPI, and FEGCG/MPI treatments (n = 4). (F, G) The cytosolic delivery efficiency of EGCG/MPI, and FEGCG/MPI complexes determined by confocal microscopy and flow cytometry. Scale bar=100μm. Data are presented as the mean ± standard deviation. *P < 0.05, **P < 0.01 by an unpaired two-tailed Student’s t-test (two groups) or one-way analysis of variance (ANOVA) with Turkey’s multiple comparisons (three groups).