Research Paper Volume 15, Issue 11 pp 4875—4888

Co-delivery of EGCG and melittin with self-assembled fluoro-nanoparticles for enhanced cancer therapy


Figure 3. Effect of FEGCG@MPI NPs on apoptosis and PD-L1 pathways. (A) Both MPI and FEGCG could reduce the ratio of Bcl-2/Bax, and the combined effect was better than MPI and FEGCG alone. (B) The results showed that the protein contents of IRF, STATT-1, P-STAT-1 and PD-L1 in FEGCG@MPI NPs group were significantly decreased. (C) The experiment was performed for three times. Data are presented as the mean ± standard deviation. *P < 0.05, **P < 0.01 by an unpaired two-tailed Student’s t-test (two groups) or one-way analysis of variance (ANOVA) with Turkey’s multiple comparisons (three groups).