Research Paper Volume 15, Issue 15 pp 7794—7810

Hmgcs2 regulates M2 polarization of macrophages to repair myocardial injury induced by sepsis


Figure 2. Inhibition of hmgcs2 aggravates myocardial injury in CLP mice. (AC) Protein contents of cTnI, CK-MB, and LDH in the serum from mice in each group. (D) Echocardiography of mice in each group. (E, F) Echocardiographic statistical analysis of left ventricular ejection fraction (LVEF) and systolic fraction (FS). (G) H&E staining of mice heart tissues in each group (magnification 400×). Sham: sham group (n = 6); Sham + ASO: sham surgery plus ASO administration group (n = 6); CLP: septic myocarditis model group in CLP operated mice (n = 6); CLP + ASO: CLP plus ASO administration group (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001: vs. sham group; #P < 0.05, ##P < 0.01, ###P < 0.001: vs. CLP group.