Research Paper Volume 15, Issue 19 pp 10031—10056

Huangqi Guizhi Wuwu decoction promotes M2 microglia polarization and synaptic plasticity via Sirt1/NF-κB/NLRP3 pathway in MCAO rats


Figure 7. EX527 dramatically blocked the efficacy of HGWD on neurological deficits and microglia polarization in MCAO rats. (A) Representative TTC staining section. (B) Quantitative analysis of infarct regions. (C) The neurological scores (mNSS). (D) Representative double-immunofluorescence staining for CD16 (red) and Iba-1 (green) markers in hippocampus. (E) Quantification of the fluorescence intensity of CD16+/Iba-1+ cells. (F) Representative double-immunofluorescence staining for CD206 (red) and Iba-1 (green) markers in the hippocampus. (G) Quantification of fluorescence intensity of CD206+/Iba-1+ cells. Scale bar: 50 μm. ##P < 0.01 vs. control group; **P< 0.01 vs. model group.