**Figure 10.** **Association of the two clusters with the TIME.** (**A**–**C**) Immune, stromal and ESTIMATE scores in the two clusters. (**D**) Heat map of the proportion of different types of immune cells. (**E**) Box plot showing differences in immune cells between the two clusters using the ssGSEA algorithm. (**F**) Box plot showing differences in immune-related functions between the two clusters using the ssGSEA algorithm. (**G**) Expression of immune checkpoint markers in the two clusters. (**H**) Histogram of proportions showing the proportion of patients with MSS, MSI-L and MSI-H in the two clusters. ^{*}*P* < 0.05, ^{**}*P* < 0.01 and ^{***}*P* < 0.001.