**Figure 7.** **Association of the CRFRs with the immune microenvironment of COAD.** (**A**) Box plot showing differences in immune cells between the high- and low-risk subgroups using the CIBERSORT algorithm. (**B**) Box plot showing differences in immune-related functions between the high- and low-risk groups using the ssGSEA algorithm. (**C**–**E**) Stromal score, immunity score and ESTIMATE score in the two risk subgroups. (**F**) Histogram of proportions showing the proportion of patients with MSS, MSI-L and MSI-H in the high- and low-risk subgroups. (**G**) Box plot of differences in risk scores for patients in the MSS, MSI-L and MSI-H subgroups. (**H**) Box plot of TMB difference for the high- and low-risk subgroups. ^{*}*P* < 0.05, ^{**}*P* < 0.01 and ^{***}*P* < 0.001.