**Figure 9.** **COAD classification based on the CRFRs.** (**A**) The cumulative distribution function curves for k = 2–9. (**B**) The tracking plot of consistent clustering. (**C**) The elbow plot showing relative change in area under the cumulative distribution function curve. (**D**) Consensus clustering matrix for k = 2. (**E**) K–M curves of the two clusters. (**F**) Sankey diagram of the association between the risk groups and clusters. (**G**, **H**) PCA and tSNE analyses of the clusters.