Research Paper Volume 15, Issue 18 pp 9572—9589

Core fucosylation regulates alveolar epithelial cells senescence through activating of transforming growth factor-β pathway in pulmonary fibrosis


Figure 8. The schematic diagram illustrated how core fucosylation regulated alveolar epithelial cells senescence in pulmonary fibrosis through TGF-β/Smad2/3 pathway in vivo and in vitro. Blocking core fucosylation modification of TGF-βR could reduce the activation of the downstream pathways of TGF-β, obstructing the process of AECs senescence and partially ameliorating lung fibrosis.