Research Paper Volume 15, Issue 18 pp 9590—9613

YY1 is regulated by ALKBH5-mediated m6A modification and promotes autophagy and cancer progression through targeting ATG4B


Figure 7. YY1 inhibition suppresses tumorigenesis in vivo. (A) Representative images, in vivo growth curve, and tumor weights of xenografts in nude mice established by the subcutaneous injection of AGS cells stably transfected with Ci-NC, Ci-YY1. (B) Representative images and IHC quantification staining showing Ki-67 protein expression in xenograft tumors. (C) Mechanisms underlying YY1-promoted autophagy and GC progression. *P < 0.05 vs. Ci-NC.