Research Paper Volume 15, Issue 18 pp 9614—9632

ALDOC promotes non-small cell lung cancer through affecting MYC-mediated UBE2N transcription and regulating Wnt/β-catenin pathway


Figure 1. ALDOC is strongly expressed in NSCLC. (A) ALDOC protein patterns were detected in NSCLC tissues compared with normal samples through IHC staining. (B) Kaplan-Meier analysis revealed the relationship between ALDOC level and patients’ overall survival. (C) Association between high ALDOC expression and poorer survival outcomes in patients with NSCLC using GEO database. (D) ALDOC mRNA levels were quantified in BEAS-2B, A549 and NCI-H1299 cells. (E, F) After infecting shALDOC and shCtrl, ALDOC mRNA and protein levels in A549 and NCI-H1299 cells were evaluated through qRT-PCR (E) and western blot experiments (F). ** P < 0.01; *P < 0.05.