Research Paper Volume 15, Issue 18 pp 9614—9632

ALDOC promotes non-small cell lung cancer through affecting MYC-mediated UBE2N transcription and regulating Wnt/β-catenin pathway


Figure 5. ALDOC regulates NSCLC through Wnt/β-catenin pathway. (A) After Wnt inhibitor treatment, the levels of ALDOC, UBE2N, c-MYC, WNT3A and β-catenin in ALDOC-overexpressing A549 and NCI-H1299 cells were investigated through western blot analysis. (B, C) After Wnt inhibitor treatment in ALDOC-overexpressing A549 and NCI-H1299 cells, the changes in cell proliferation (B) and apoptosis (C) were evaluated via CCK8 and flow cytometry assays. *** P < 0.001; *P < 0.05.