**Figure 1.** **Genetic variations and biomarker screening of CRGs in RCC.** (**A**) Summary of variation in alive RCC patients. The x axis represents the number of mutations, and the y axis represents the category of mutation. (**B**) Genetic mutations landscape of 19 CRGs in alive RCC patients. (**C**) Summary of variation in dead RCC patients. The x axis represents the number of mutations, and the y axis represents the category of mutation. (**D**) Genetic mutations landscape of 19 CRGs in dead RCC patients. (**E**) Analysis of TMB difference in patients with different survival status of RCC. (**F**) K-M curve for RCC patients with different TMB score. H, represents high TMB group as measured by the median value. L, represents low TMB group as measured by the median value. (**G**) Expression level of CDKN2A in patients with different survival status of RCC. (**F**) K-M curve for RCC patients with different CDKN2A expression level. (**H**) represents high expression group as measured by the median value. L, represents low expression group as measured by the median value. (**I**, **J**) Results of univariate (**I**) and multivariate (**J**) Cox regression for CDKN2A and different clinical features. ^{*}*p* < 0.05. ^{**}*p* < 0.01.