Research Paper Volume 15, Issue 18 pp 9743—9758
NOTCH2 gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer
Figure 8. Signaling pathways for tumorigenesis effects by NOTCH2 mutation. Apoptosis effects through the pAKT-Bax/Bcl-2 and pNF-κB/Rel pathways. Meanwhile, NOTCH2 mutation promoted tumor cell migration, invasion, and proliferation through Hes 1 and TAMs involved in the tumor microenvironment (TME). Abbreviations: NICD: Notch2 intracellular domain; TAMs: tumor-associated macrophages.