Research Paper Volume 15, Issue 18 pp 9822—9841

Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma


Figure 4. PTPN6 shapes the immunosuppressive TME in GBM. (A) Influence of PTPN6 with immune cell infiltration across different cancer. (B) TME comparison based on PTPN6 expression in GBM. (C) Association between PTPN6 and six immunosuppressive molecules across pan-cancer types. (D) Correlation of PTPN6 with activated CD8+ T cells and T cell exhaustion in different cancer types. (E) Correlation of PTPN6 with immunosuppressive cells and their representative marker genes. *P < 0.05, **P < 0.01, ***P < 0.001.