Research Paper Volume 15, Issue 18 pp 9822—9841

Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma


Figure 6. PTPN6 promotes GBM progression. (A) PTPN6 protein expression level is up-regulated in GBM human samples compared with the paired adjacent tissue. (B) PTPN6 overexpression accelerates glioma cell proliferation. (C) PTPN6 knockdown inhibits glioma cell proliferation. (D) PTPN6 overexpression inhibits glioma cell apoptosis; and promotes cell apoptosis after PTPN6 knockdown. (E) PTPN6 overexpression promotes cell cycles; and inhibits cell cycles after PTPN6 knockdown. (F) PTPN6 promotes GBM tumorigenesis in vivo. (G, H) Calculation of GBM nidus from (F), **P < 0.01. (I) Evaluating the GBM TME in C57 mice (n = 6, biological repetition = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001.