Research Paper Volume 15, Issue 19 pp 10105—10116

SNHG25 promotes colorectal cancer metastasis by regulating MMP2


Figure 1. SNHG25 is up-regulated in CRC and its expression level is related to prognosis. (A) The heatmap shows the abnormal expression of lncRNAs in CRC in TCGA database. Red color indicates up-regulated in CRC, and blue color indicates down-regulated in CRC. SNHG25 is marked with a red underline. (B) Expression of SNHG25 in CRC generated from RNA sequencing data from TCGA database. (C) SNHG25 expression was detected by qRT-PCR in 90 pairs of CRC tissues and adjacent normal tissues. (D) Representative images of ISH assays for detecting SNHG25 in CRC tissues and corresponding normal tissues. (E) The expression of SNHG25 in NCM460, HCT-8, LOVO, HCT-116, SW480 and HT-29 cells was detected by qRT-PCR. (F) Kaplan-Meier survival curves and log-rank tests were used to compare the survival time between the high SNHG25 expression group and the low SNHG25 expression group. The top 50% of the samples were considered as high expression of SNHG25, and the bottom 50% samples considered as low SNHG25 expression. *P < 0.05, **P < 0.01 and ***P < 0.001.