Research Paper Volume 15, Issue 19 pp 10237—10252
Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3/caspase-1 pathway in Alzheimer’s disease
Figure 9. Detection of intracellular protein expression of ASC, NLRP3, and caspase-1 by western blotting. (A) Western blotting. Lane 1, WT group (treated with normal saline); lane 2, APP/PS1 group (treated with normal saline); lane 3, APP/PS1 + ginkgolide group (treated with 1.75 mg/kg ginkgolide); lane 4, APP/PS1 + donepezil group (treated with 0.65 mg/kg donepezil). (B–D) Effects of ginkgolide on the protein levels of ASC, NLRP3, and caspase-1 in the brains (hippocampus and cortex) of APP/PS1 transgenic mice. Data are presented as mean ± standard deviation. Abbreviations: ASC: apoptosis-associated speck-like protein containing a CARD; APP/PS1: amyloid precursor protein/presenilin 1; NLRP3: nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3; WT: wild-type.