Research Paper Volume 15, Issue 19 pp 10291—10306

Dendrobium officinale polysaccharide decreases podocyte injury in diabetic nephropathy by regulating IRS-1/AKT signal and promoting mitophagy


Figure 1. High glucose treatment induced oxidative stress and IR in MPC5 cells. (A) HG inducement distinctly reduced glucose consumption of MPC5 cells compared with normal glucose-treated group. (B) HG inducement notably augmented generations of malondialdehyde (MDA). (CE) The phosphorylation of insulin receptor substrate (IRS)-1 (phospho Y632), AKT (phospho Ser473) and AKT (phospho Thr308) was markedly reduced by HG inducement. Besides, the expression of Nephrin was also notably decreased by HG inducement. (*P < 0.05; ** p < 0.01; *** p < 0.001, n=3).