Research Paper Volume 15, Issue 20 pp 10897—10914

WNT enhancing signals in pancreatic cancer are transmitted by LGR6


Figure 2. LGR6 expression correlates with epithelial signatures. (A) Super TOP/FOP assays (STF assay) revealed higher baseline WNT activity levels in epithelial (green) vs. mesenchymal (blue) pancreatic cancer cells. (B) Clustering of gene expression in the same cell lines affiliates LGR6 with WNTpositive epithelial signature, whereas the WNTnegative mesenchymal signature was highly expressed in mesenchymal PDAC cell lines (blue). (C) Epithelial WNT niche subtypes described by Seino and colleagues clustered with LGR6 in CCLE and TCGA datasets. *, P<0.05; **, P<0.01; ***, P<0.001.