Research Paper Volume 15, Issue 20 pp 10897—10914

WNT enhancing signals in pancreatic cancer are transmitted by LGR6


Figure 4. LGR6 depletion correlates with reduced cancer stemness. (A) sphere formation ability (SFA) and qPCR of LGR6 and WNT target gene AXIN2 in vector control treated cells. Stimulation with RSPO2, WNT3a or its combination leads to increased SFA, and LGR6/AXIN2. Knock-down of LGR6 (B) reduces SFA and influences LGR6 and AXIN2 gene expression, suggesting partial regulation of canonical WNT through LGR6.