Research Paper Volume 15, Issue 20 pp 10897—10914

WNT enhancing signals in pancreatic cancer are transmitted by LGR6


Figure 5. LGR6 is higher expressed in PDAC compared to normal tissue and trends towards worse overall survival. (A) Analysis of publicly available datasets (GSE62165, GSE16515, and GSE71729) shows significantly more LGR6 in tumor vs. normal pancreatic tissue (NP). (B) ROC curve analysis of normalized LGR6 mRNA expression for best discrimination threshold with an area under the curve (AUC) of 0.6565. (C) Dichotomal classification revealed a trend of high LGR6 expression and poor overall survival; survival of PDAC patients of LGR6high versus LGR6low is decreased without statistical significance.