Research Paper Volume 16, Issue 6 pp 5065—5076

The protective effects of Irbesartan in cognitive impairment in hypertension


Figure 5. Irbesartan repressed CDK5 activity and reversed BDNF reduction in the hippocampus of SHR rats. (A) CDK5 activity (% of maximal activity) was determined by ELISA. (B) Protein level of p35/p25 and p-Tau (pSer214)/Tau46. (C) Protein level of BDNF(n=6,**, P< 0.01 vs. WKY group; #, ##, P<0.05, 0.01 vs. SHR group).