Research Paper Volume 16, Issue 6 pp 5545—5566

A pyrimidine metabolism-related signature for prognostic and immunotherapeutic response prediction in hepatocellular carcinoma by integrating analyses


Figure 12. Suppression of DCK inhibited the proliferative and migrative ability of LIHC cells. (A) Transfected efficiency of three siRNAs targeting DCK. (B, C) The activity of MHCC-97H and HepG2 cell lines was dramatically inhibited following DCK knockdown. (D, E) Colony formation assay revealed that the capacity of these two cell lines to generate colonies was significantly decreased after DCK knockdown. (FI) The migrative and invasive ability of MHCC-97H and HepG2 cell lines was considerably suppressed in the transwell assay and wound healing experiment. (*P<0.05, **P<0.01, ***P<0.001, ****P<0.0001).