Research Paper Volume 16, Issue 7 pp 5905—5915

Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway


Figure 4. Cepharanthine (CEP) reduced the expression of VEGF-A and VEGFR2 in the cortex of MCAO mice model. (A) mRNA levels of VEGF-A and VEGFR2; (B) Protein levels of VEGF-A and VEGFR2 as measured using immunostaining. Scale bars, 100 μm (**, P<0.01 vs. vehicle group; ##, P<0.01 vs. MCAO group).