Research Paper Volume 16, Issue 7 pp 5905—5915

Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway


Figure 5. Cepharanthine (CEP) ameliorated cytotoxicity of human bEnd.3 brain microvascular endothelial cells against hypoxia/reperfusion (H/R). Cells were exposed to hypoxia/reperfusion condition (6 h/24 h) with or without CEP (1.5, 3 μM). (A) Cell viability measured by MTT assay; (B) LDH release (**, P<0.01 vs. vehicle group; #, ##, P<0.05, 0.01 vs. H/R group).